Co-processed excipient combining microcrystalline cellulose and guar gum for sustained release and controlled drug delivery systems
MCC & Guar Gum is a co-processed excipient that combines the excellent binding and disintegrating properties of microcrystalline cellulose with the sustained release characteristics of guar gum. This innovative combination provides controlled drug release profiles ideal for extended-release formulations.
Provides controlled drug release over extended periods
Superior binding properties from MCC component
Forms hydrophilic matrix for controlled release
Optimized combination for enhanced performance
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | White to off-white powder | Visual |
| Identification | Complies | USP/Ph.Eur |
| MCC Content | 75-85% | HPLC |
| Guar Gum Content | 15-25% | HPLC |
| Particle Size Distribution | D50: 50-200 μm | Laser Diffraction |
| Moisture Content | ≤ 5.0% | Karl Fischer |
| pH (1% suspension) | 5.0 - 7.5 | USP |
| Bulk Density | 0.25 - 0.45 g/cm³ | USP |
| Tapped Density | 0.35 - 0.65 g/cm³ | USP |
| Carr's Index | ≤ 25% | Calculated |
| Hausner Ratio | ≤ 1.33 | Calculated |
| Heavy Metals | ≤ 10 ppm | USP |
| Lead | ≤ 2 ppm | USP |
| Total Aerobic Count | ≤ 1000 CFU/g | USP |
| Yeast & Mold | ≤ 100 CFU/g | USP |
| E. coli | Absent/g | USP |
| Salmonella | Absent/25g | USP |
Primary application in sustained release tablet formulations for controlled drug delivery.
Forms hydrophilic matrix for controlled drug release over extended periods.
Ideal for once-daily dosage forms requiring 12-24 hour drug release.
Suitable for direct compression processes with excellent flow properties.
Commonly used in cardiovascular drug formulations requiring sustained release.
Effective for central nervous system drugs requiring controlled release profiles.
Our MCC & Guar Gum meets the stringent requirements of major international pharmacopeias
United States Pharmacopeia - National Formulary
European Pharmacopoeia
Japanese Pharmacopoeia
Indian Pharmacopoeia