Carboxymethylcellulose Calcium
CARMELLOSE CALCIUM
Importance of bio-availability and fast disintegration of pharmaceutical tablet is realized and awarness for super-disintegrants in pharmaceutical tablet formulation has also increased. Superdisintegrant viz. Sodium Starch Glycollate was also introduced by Maple Biotech Pvt Ltd. in year 1991, which was appreciated in quality and performance by pharmaceutical industry . Although quest for superior quality superdisintegrant was not over. Superdisintegrant with better stability and superior performance at high tablet hardness level was sought and Maple Biotech’s R & D department developed the product Crosslinked Sodium Carboxy Methyl Cellulose which is bearing brand name Cel-Ca-Dissol®. Further taking into consideration the requirement for faster dissolution aid for tablets containing ingredients having poor solubility, Calcium Carboxymethylcellulose (Carmellose Calcium) was introduced.
Properties
Carmellose calcium is white or creamish white in colour. Chemically, it is calcium salt of carboxy methyl cellulose with very high degree of purity.
Very hard tablets with other superdisintegrants do not perform as well as Carmellose Calcium performs. Quantity to be used in pharmaceutical formulation is very less. Carmellose Calcium helps in dissolution of drugs having poor solubility
Advantages
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Fastest dissolution of Drug material
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good water uptake
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high capillary action
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rapid swelling properties
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efficient fluid channeling compatibility with most actives and excipients
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excellent long-term stability
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low usage level
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low cost-in-use
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very fast drug dissolution